I think you'll be fine, and you've got a good grasp on what can go wrong. If you've not hiked the Ozarks before I'll offer that ten miles a day here with a 45 lb pack can be a wearing trip, but if you're in good shape you should do okay.

I generally keep my trips here to under ten miles because you have to go slower on these rocky and steep trails we have most place.

What's easy to forget is that trail miles are measures on the flat (as the crow flies so to speak). There are no flat trails here and all that up and down adds distance, and it's far and away the hard part of that distance, but it's not even measured in with it.

So take your time. Don't rush up or down those rocky trails just to make a milage goal. More than any other thing that's what I see that leads to injury here.

BTW, where in the Ozarks are you hiking?