Good points OM, especially with the aspirin remarks. Asprin can be harmful to the liver over long periods of use. I'm talking Tylenol and those types, don't know about baby asprin. Hmm, I have a detached retina too and never related it to asprin use (before I heard of liver damage and stopped using it).

300winmag, you made some intersting points with the no2 use. It is pricey but for extreme trips at altitude for folks from lower altitudes it might make sense after a doctor chat prior to the trip.