The Smokies have great wildflowers in spring. Check the park's website, and note there are several 2- and 3-day and longer options out of Big Creek, a beautiful campground convenient to the interstate. Note there are also many mountain hiking areas closer to Florida, where you don't need reservations, such as the Foothills Trail, north Georgia, Panthertown Valley and the Standing Indian Loop area. Though flat and requiring reservations, Cumberland Island also is beautiful.