Just the opposite: I've never had a serious blister since I ditched the boots and went exclusively to trail runners. In addition, I've had less fatigue, fewer (in fact, none) turned ankles, fewer balance issues. I also wear Smartwool PhD socks which conform better to my feet---they don't slip around as much as most socks.

Feet are extremely individual. I believe that each person needs to experiment with shoe fit, socks, diet, conditioning and the many other factors involved to find out what works for them as an individual.

In other words, YMMV!!!