I have been trying to figure a reason why a PLB might be an issue and can't think of one. My only advice is to make sure that there is no possible way you could accidentally set it off! One of my crew members set one off accidentally mid-flight one time and it made for an interesting next few hours. Had it not been Christmas Day it might not have been quite the issue it was, LOL.

MNS a/k/a Dixie Moon
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YMMV. Viewer discretion is advised.