Katie, As far as altitude goes, there is at least one thread here on that from a couple of months ago, I think. My advice is to acclimate slowly, whether that means taking it easy for the first few days or slowly working you way up to altitude. Take along something for headaches, if you get one and drink plenty of fluids. Altitude sickness is nothing to take lightly.
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Don't get me started, you know how I get.