I have no scientific information as far as how much harm is done to the bag etc. My personal philosophy is leave it uncompressed whenever possible. I will compress mine quite a bit and place it into the bottom of my pack the night before I go camping. When I return from my overnight adventure or two I turn it inside out, air it out, and place it back in its regular large storage bag. I don’t worry about it much. I bought it to use, and when it is no longer usable I will buy another.

Howie