A good three night hike into Arizona high-country is the hike into Manning Camp in the Rincon Mountains east of Tucson. This is part of Saguaro National Park so permits are required for all overnight trips into the back country. A good itinerary would be: day 1; Tanque Verde Ridge trail-head in the park, near Tucson, to Juniper Basin camp; day two, Juniper Basin to Manning Camp; day 3, Manning Camp to Grass Shack camp and day 4 out. There is permanent water at Manning Camp and seasonal water at Juniper and Grass Shack. Check on the water status when you get your permit and have the containers to carry at least a gallon if one or more of the seasonal sources are dry. Also, carry something like a coffee filter to strain the floaties and wildlife out of your water if you don't like chewing it before you swallow; some of the water is pretty grungy looking. Also carry a water treatment like pills or a filter.

Get an early start the first day because the weather here is getting hot. Once you gain a couple of thousand feet it is quite a bit cooler. Manning camp is at 8,000 feet.

Added in editing: My avatar photo was taken near Manning Camp.