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Once I hit 30 I found my knees couldn't take the abuse any more. I started using trekking poles, a knee brace, lighter gear, more stretching, and better hydration, they all seem to have a positive impact.
This echoes my experience. The kneebraces were at the suggestion of my doctor, the trekking poles were from reading here. Both made a huge positive impact on my hiking life. I probably couldn't hike at all if it weren't for these things.
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PhilBIker