Here is a list of vetted charities working in Nepal:

http://www.charitynavigator.org/index.cfm?bay=content.view&cpid=1888#.VUDxECFVhBc

When my wife and I went through this exercise sometime back we decided to give to Americares. I hadn't heard of them before, but they seem to consistently show up at the top of the ratings and being involved in these disaster areas. The charities I had heard of seem to spend a lot of money on advertising and CEO pay (which is probably why I had heard of them).