hmmm for the same amount of weight I would skip the .22 and carry my colt .45.
I certainly wouldn't plan on shooting at anything really long distance with a .22 and if I am taking an aimed shot with a good rest, I can make a 25 yard shot with my .45 and hit just about anything.
Now if I was trying to get a squirrel for some quick meat, the .45 would certainly not be a good option, but it will take out a mean wild pig if needed. I wouldn't try it with a bear. Its still better to avoid them all together.